|
Laryngeal Squamous Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To determine the frequency of the genotype of signal transducer and activator of transcription protein 3 (STAT3) rs744166, sirtuin (SIRT1) rs12778366, fibroblast growth factor (FGFR2) rs2981582, and advanced glycosylation end product-specific receptor (RAGE) rs1800625 gene polymorphisms in patients with laryngeal squamous cell carcinoma (LSCC).
|
31781300 |
2019 |
|
Aplastic Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Current study results support that functional STAT4 (rs7574865), IL23R (rs11209032), and STAT3 (rs744166) variants may associate with occurrence, severity, and immunosuppressive outcome of AA in the Han population in southwest China.
|
29330562 |
2018 |
|
Pituitary Adenoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
STAT3 rs744166 polymorphism analysis in the overall group revealed differences in the genotype distribution between patients with PA and the control groups.
|
28521414 |
2017 |
|
Stomatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Both multiple logistic regression analysis and Cox proportional-hazards regression analysis show STAT3 rs744166 TT+TC genotypes and serum creatinine in each patient were significant independent factors for stomatitis development.
|
28381801 |
2017 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
The presence of (C) in rs10758669, (T) and (TT) in rs957970, and (TT) in rs744166 were found to increase the susceptibility to Crohn's disease (p=0.049, p=0.016, p=0.010, p=0.035, respectively), while rs2293152 (GC), rs744166 (CT), and rs957970 (CT) provide protection against Crohn's disease (p=0.007, p=0.043, p=0.043, respectively).
|
27852544 |
2016 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Our results support an important association of rs744166 and rs4796793 with decreased CD risk, and additional interaction between rs744166 and smoking.
|
27022745 |
2016 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Associations between potentially functional IL6 (rs2069837 and rs1800795) and STAT3 (rs744166 and rs4796793) SNPs and clinical outcomes [progression-free survival (PFS), overall survival, and tumor response rate] were evaluated in mCRC patients receiving first-line FOLFIRI plus bevacizumab in two randomized phase III trials: TRIBE (n = 223, training cohort) and FIRE-3 (n = 288, validation cohort).
|
26839145 |
2016 |
|
Hashimoto Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Allele A of STAT3 SNP rs744166 A>G was significantly more frequent in both HT and GD patients, while allele G was significantly more frequent in the control group.
|
26204395 |
2015 |
|
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Allele A of STAT3 SNP rs744166 A>G was significantly more frequent in both HT and GD patients, while allele G was significantly more frequent in the control group.
|
26204395 |
2015 |
|
Inflammatory Bowel Diseases
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study provides evidence that STAT3 rs744166 G allele and infection with CagA-positive H. pylori with higher number of EPIYA-C segments are independent risk factors for gastric cancer.
|
26186918 |
2015 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study provides evidence that STAT3 rs744166 G allele and infection with CagA-positive H. pylori with higher number of EPIYA-C segments are independent risk factors for gastric cancer.
|
26186918 |
2015 |
|
Gastritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs744166 polymorphism (p = 0.001; OR = 1.64; 95 % CI = 1.16-2.31) and infection with H. pylori CagA-positive strains possessing higher number of EPIYA-C segments (p = 0.001; OR = 2.28; 95 % CI = 1.41-3.68) were independently associated with gastric cancer in comparison with gastritis.
|
26186918 |
2015 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the STAT3 rs12949918 and rs744166 polymorphisms, but not other three polymorphisms, may be an important protective factor for cancer.
|
26063618 |
2015 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the STAT3 rs12949918 and rs744166 polymorphisms, but not other three polymorphisms, may be an important protective factor for cancer.
|
26063618 |
2015 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians.
|
25286337 |
2014 |
|
Ulcerative Colitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians.
|
25286337 |
2014 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that rs744166 in STAT3 was associated with colon cancer risk in two studies; however, the direction of the observation was reversed in TP53 mutant tumors possibly due to a nullification of the effect by mutant p53.
|
25132422 |
2014 |
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that rs744166 in STAT3 was associated with colon cancer risk in two studies; however, the direction of the observation was reversed in TP53 mutant tumors possibly due to a nullification of the effect by mutant p53.
|
25132422 |
2014 |
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that rs744166 in STAT3 was associated with colon cancer risk in two studies; however, the direction of the observation was reversed in TP53 mutant tumors possibly due to a nullification of the effect by mutant p53.
|
25132422 |
2014 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
STAT3 rs744166 and rs4796793 polymorphisms may be associated with CD occurrence and used as a predictive factor of CD in Chinese Han populations.
|
24885273 |
2014 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Collectively, rs744166 polymorphism might be significantly associated with a decreased risk of gastric cancer in a Chinese population.
|
24864251 |
2014 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
Collectively, rs744166 polymorphism might be significantly associated with a decreased risk of gastric cancer in a Chinese population.
|
24864251 |
2014 |
|
Hashimoto Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we genotyped three single nucleotide polymorphisms (SNPs) within the IL-23R (rs11209026/p.Arg381Gln, rs7530511) and STAT3 (rs744166) genes in 217 Croatian patients with HT and 161 healthy controls using fluorescence resonance energy transfer technology and melting curve analysis of polymerase chain reaction products.
|
24460100 |
2014 |
|
Arthritis, Psoriatic
|
|
0.010 |
GeneticVariation
|
BEFREE |
A statistically significant association of the STAT3 rs744166(∗)G allele with PsA was observed (P-value=1.36×10(-3), OR 1.35).
|
23127549 |
2013 |